FOXBOX呼吸代谢技术助力右美托咪定治疗COVID19重症患者研究
据SSI呼吸代谢技术官网2022年1月20日最新参考信息，镇静剂右美托咪定可能有助于治疗重症监护中的新冠肺炎患者——但它如何影响呼吸和血压？
右美托咪定可维持一定程度的镇静状态，有利于降低机体的氧耗率，改善氧合。来自日本牙科大学的科学家采用Foxbox呼吸代谢技术构建了如下图所示的镇静
相关研究成果见2022年1月14日PLOS ONE在线论文“Effect of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing adult rats”。
参考资料
1.Zhou L, Gu W, Kui F, et al. The mechanism and candidate compounds of aged citrus peel (chenpi) preventing chronic obstructive pulmonary disease and its progression to lung cancer. Food & Nutrition Research. 2021 ;65. DOI: 10.29219/fnr.v65.7526.
2.Wearing, O.H., Ivy, C.M., Gutiérrez-Pinto, N. et al. The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice. BMC Biol 19, 128 (2021).
3.Catherine M.Ivy,Haley Prest,Claire M.West,and Graham R.Scott. Distinct Mechanisms Underlie Developmental Plasticity and Adult Acclimation of Thermogenic Capacity in High-Altitude Deer Mice. Front Physiol. 2021;12:718163. 11.doi:10.3389/fphys.2021.718163.
4.右美托咪定在临床麻醉中的优势地位 (baidu.com)
5.新冠危重症患者七点治疗经验_医师网-《医师报》官网 (mdweekly.com.cn)
参考资料
1.Zhou L, Gu W, Kui F, et al. The mechanism and candidate compounds of aged citrus peel (chenpi) preventing chronic obstructive pulmonary disease and its progression to lung cancer. Food & Nutrition Research. 2021 ;65. DOI: 10.29219/fnr.v65.7526.
2.Wearing, O.H., Ivy, C.M., Gutiérrez-Pinto, N. et al. The adaptive benefit of evolved increases in hemoglobin-O2 affinity is contingent on tissue O2 diffusing capacity in high-altitude deer mice. BMC Biol 19, 128 (2021).
3.Catherine M.Ivy,Haley Prest,Claire M.West,and Graham R.Scott. Distinct Mechanisms Underlie Developmental Plasticity and Adult Acclimation of Thermogenic Capacity in High-Altitude Deer Mice. Front Physiol. 2021;12:718163. 11.doi:10.3389/fphys.2021.718163.
4.右美托咪定在临床麻醉中的优势地位 (baidu.com)
5.新冠危重症患者七点治疗经验_医师网-《医师报》官网 (mdweekly.com.cn)
