Naturethink 技术文章

2368 次 FAK 通过 Drp1 调控心肌细胞线粒体裂变和功能 2024-12-16
FAK regulates cardiomyocyte mitochondrial fission and function through Drp1Keywords: Drp1; FAK; fibronectin; mitochondrial fission.线粒体对于心肌细胞的能量产生至关重要，其功能障碍与
2817 次机械应力经TGF-β1 激活 Smad2/3 并抑制 NF-κB 以防软骨细胞焦亡 2024-12-16
Mechanical stress protects against chondrocyte pyroptosis through TGF-β1-mediated activation of Smad2/3 and inhibition of the NF-κB signaling pathway in an osteoarthriti
1842 次动脉粥样硬化中血流紊乱会损害MerTK介导的主动脉内皮细胞的胞葬作用 2024-12-9
Disturbed flow impairs MerTK-mediated efferocytosis in aortic endothelial cells during atherosclerosisKeywords: Disturbed flow; MerTK; RNA-seq; atherosclerosis; efferocytosis; prot
1940 次机械敏感的多囊蛋白1促进骨膜干/祖细胞在骨折愈合中的骨软骨分化 2024-12-9
Mechanosensitive protein polycystin-1 promotes periosteal stem/progenitor cells osteochondral differentiation in fracture healingKeywords: Fracture healing; Mechanical stress; Peri
1582 次 TNFSF12/TWEAK调节结肠炎性成纤维细胞并促其与单核细胞相互作用 2024-12-2
The TNFSF12/TWEAK Modulates Colonic Inflammatory Fibroblast Differentiation and Promotes Fibroblast-Monocyte InteractionsKWS：TNFSF12/TWEAK；Colonic Inflammatory Fibroblast；Differ
1287 次 miR-342-5p通过抑制 MYC增强内皮细胞对剪切力的动脉化响应 2024-12-2
miR-342-5p downstream to Notch enhances arterialization of endothelial cells in response to shear stress by repressing MYCKeywords: MT: Non-coding RNAs; Notch; arterialization; end
1758 次激活的SIRT1 通过增强 H 型血管生成和骨形成的耦联来促进骨修复 2024-11-25
SIRT1 activation promotes bone repair by enhancing the coupling of type H vessel formation and osteogenesisKWS：SIRT1；bone repair；type H vessel formation；osteogenesis骨缺损可由感
2433 次血管内皮细胞机械敏感基因在动脉粥样硬化形成和治疗中的研究进展 2024-11-25
Recent advances of mechanosensitive genes in vascular endothelial cells for the formation and treatment of atherosclerosisKeywords: Atherosclerosis; Blood flow; Endothelial cell; M
1744 次 CD97 在压缩下通过 Rap1a/ERK 通路抑制破骨细胞分化 2024-11-18
CD97 inhibits osteoclast differentiation via Rap1a/ERK pathway under compressionSubject terms: Orthodontics, Cell signalling正畸治疗是通过正畸牙齿移动（OTM）矫正咬合不正。OTM 是一种
3204 次 Piezo1 介导的机械转导导致血流紊乱诱导的动脉粥样硬化内皮炎症 2024-11-18
Piezo1‐Mediated Mechanotransduction Contributes to Disturbed Flow‐Induced Atherosclerotic Endothelial InflammationKeywords: Piezo1; atherosclerosis; endothelial cells; inflammati
1622 次绿茶化合物EGCG在子痫前期的体外静态和剪切应力模型中的抗氧化作用 2024-11-16
EGCG, a Green Tea Compound, Increases NO Production and Has Antioxidant Action in a Static and Shear Stress In Vitro Model of PreeclampsiaKeywords: EGCG; NO; antioxidant; endotheli
1552 次电压门控性钙通道α2δ亚基-1调控结肠癌进展并影响其微环境 2024-10-28
CACNA2D1 regulates the progression and influences the microenvironment of colon cancerKeywords: CACNA2D1; Colon cancer; Fibroblast; Voltage-gated calcium channel; p53.近年来，由于化
1263 次人牙周膜间充质基质细胞通过旁分泌和细胞接触介导对CD4+T的免疫调节 2024-10-28
Paracrine- and cell-contact-mediated immunomodulatory effects of human periodontal ligament-derived mesenchymal stromal cells on CD4+ T lymphocytesKeywords: CD4+ T lymphocytes; Co-
1466 次衰老诱导内皮受损金属蛋白酶17脱落连接粘附分子-A导致动脉重塑 2024-10-28
Aging-induced impaired endothelial wall shear stress mechanosensing causes arterial remodeling via JAM-A/F11R shedding by ADAM17Keywords: Aging; Endothelium dysfunction; F11R; Junc
1898 次 BACH1 基因的缺失通过减少内皮炎症减轻动脉粥样硬化 2024-10-28
Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial InflammationKeywords: BACH1; YAP; atherosclerosis; endothelial inflammation; hemodynamics.动脉粥样硬化是冠状动脉
1457 次流体剪切应力通过NKG2D增强自然杀伤细胞对循环肿瘤细胞的细胞毒性 2024-10-25
Fluid shear stress enhances natural killer cell's cytotoxicity toward circulating tumor cells through NKG2D-mediated mechanosensingTopics：Mechanical stress, Cytotoxicity, Degr
1661 次与体外循环相关剪切应力诱导单核细胞炎性细胞因子和坏死性凋亡的表达 2024-10-25
Shear stress associated with cardiopulmonary bypass induces expression of inflammatory cytokines and necroptosis in monocytesKeywords: Calcium signaling; Cardiology; Cytokines; Inf
1789 次线粒体蛋白去琥珀酰化通过调节线粒体稳态介导压缩诱导的椎间盘退变 2024-10-25
SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasisSubject terms: Dise
1969 次电压门控性钙通道α2/δ亚基-1调控结肠癌的进展并影响结肠癌的微环境 2024-10-21
近年来，由于化疗的进步和分子靶向药物的出现，结肠癌（CC）的治疗结果有所改善。离子转运体（Ion transporters）在细胞功能中起着至关重要的作用，近年来作为癌症的潜在治疗靶点而受到关注。阐
1648 次衰老致内皮剪切应力感损去整合素金属蛋白酶介导粘附分子脱落动脉重塑 2024-10-21
随着年龄的增长，心血管系统发生了重要变化，包括血管硬度升高和异常重塑。研究表明，与衰老相关的小阻力动脉重塑可以独立于全身血压的变化而发生。研究已表明，小阻力动脉会因血流的持久变化或