高通量测序与系统生物学研讨会报名通知

高通量测序与系统生物学研讨会

时间：2009年12月9日
地点：中科院上海生科院生科大楼二楼报告厅（岳阳路320号）

近年来，高通量测序技术已广泛应用于生物学研究的各个领域，很多生物学问题都可以借助高通量DNA测序技术予以解决。目前，上海伯豪生物技术有限公司（简称SBC，上海生物芯片有限公司下属CRO子公司）和国家人类基因组南方研究中心协作互助，先后建立了Roche 454技术平台, Illumina Solexa技术平台和ABI SOLiD技术平台，已拥有ABI SOLiD3（5台）、Roche Genome Sequencer FLX（1台）和Illumina Genome Analyzer IIx（1台），从而迅速成长为华东地区最大的高通量测序中心。

2009年末，SBC正式对外推出“SBC高通量测序系统解决方案”，将新一代DNA测序技术与生物芯片技术相结合，协助广大科研工作者以更低廉的价格，更全面、更深入地分析基因组、转录组及蛋白质组的各项数据。力争尽快将高通量测序技术及生物芯片技术成为广泛使用的常规实验手段，从而为生物学研究领域带来革命性的变革。

主持人: 肖华胜博士（上海伯豪生物技术有限公司常务副总裁/生物芯片上海国家工程研究中心执行主任）

08:45-09:00 签到及领取资料和午餐券（提供麦当劳或肯德基套餐）

09:00-10:00 人基因组全外显子捕获+高通量深度测序 —Agilent SureSelect Exon Capture + ABI SOLiD技术

报告人： 杨晓楠博士（上海伯豪生物技术有限公司高通量测序平台技术负责人）

10:00-11:00 Functional Mutation Detection on SOLiD: A Practical Guide

报告人：Dr. Jeffrey G. Reid (Assistant Professor, Applied Biosystem Inc.)

Abstract: With the recent rapid increases in sequence yield it is easier now more than ever to produce the raw sequence data required for building a whole personal genome. However, there are a number of computational challenges to be faced in building a list of functional variants from the raw sequence data. The purpose of this presentation is to provide some insights into this process from the perspective of population-based sequencing approaches, cancer sequencing of tumor/normal pairs, and the discovery of functional variants in high-penetrance genetic disorders. Practical solutions to real-world data production and analysis problems will be discussed.

11:00-12:00 Empower the Sequence Efficiency with Agilent SureSelect Target Enrichment System

报告人：Dr. Jian Li (Business Channel Manager, Agilent Technologies Inc.)

Abstract: Current generation DNA sequencers have revolutionized genomics research through dramatic increases in throughput and spiraling reduction in costs. However, the large throughput of next generation sequencers also present data analysis bottlenecks/challenges. Such challenges have motivated researchers to increasingly focus their sequencing efforts on genomic regions that matter most to their interests. Agilent’s SureSelect Target Enrichment System takes advantage of the exceptional fidelity in 200-mer oligonucleotides synthesis to custom-design genomic regions of interest for targeted capture through a user-friendly web-portal, eArray. The target enrichment system uses both on-array and in-solution phase methods that are uniquely suited to meet researchers’ throughput and automation needs. While the on-array method uses 60-mer DNA oligos to capture 750 kb to 1 Mb genomic regions, the solution-phase method uses 120-mer biotinylated RNAs to capture Mb to whole exon regions to further increase the sequence efficiency. Agilent’s Target Enrichment system is developed and optimized for SOLiD platform as well as other NGS platforms.

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