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1308 次 神经系统中关键受体NK3R的功能作用及相关实验的介绍 2025-7-10
NK3R（速激肽受体3）是由TACR3基因编码的一种蛋白质。它属于速激肽受体家族，是一种典型的G蛋白偶联受体。NK3R发挥功能的关键在于结合其高亲和力配体——神经激肽B(NKB)。NK3R不仅参与
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984 次 压力响应型 miRNA - 5703 的过表达抑制压力诱导的肝癌生长和转移 2025-7-9
Overexpression of pressure-responsive miRNA-5703 inhibits pressure-induced growth and metastasis of liver cancerKeywords: liver cancer; metastasis; miRNA-5703; portal hypertension;
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1174 次 成纤维细胞中张力敏感的 HOX 基因表达用于差异瘢痕形成 2025-7-8
Tension-sensitive HOX gene expression in fibroblasts for differential scar formationKeywords: Scar formation, Hypertrophic scar; Keloid; Wound healing; Tension; Tension change; Ten
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1209 次 C/EBPβ 拮抗剂诱导巨噬细胞促炎极化增强抗肿瘤免疫 2025-7-3
The C/EBPβ antagonist peptide lucicebtide (ST101) induces macrophage polarization toward a pro-inflammatory phenotype and enhances anti-tumor immune responsesKeywords: C/EBP&b
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1327 次 小鼠主动脉应力激活平滑肌细胞适应性程序维持强度防动脉瘤和夹层 2025-6-30
Aortic Stress Activates an Adaptive Program in Thoracic Aortic Smooth Muscle Cells That Maintains Aortic Strength and Protects Against Aneurysm and Dissection in MiceKeywords: aort
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1415 次 成骨细胞线粒体氧化应激或自噬减少不足以模拟衰老对骨机械反应性损害 2025-6-24
Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsivenessKeywords:
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883 次 苔藓抑素-1（Bryostatin-1）通过抑制内皮细胞自噬改善动脉功能 2025-6-24
Bryostatin-1 improves function in arteries with suppressed endothelial cell autophagyKeywords: Aging; Bryostatin-1; Endothelial cell; Nitric oxide.内皮功能障碍是心血管衰老的标志，内
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1044 次 Piezo1 对抗与衰老相关的皮质骨丢失 2025-6-24
Piezo1 opposes age-associated cortical bone lossKeywords: Piezo1; age-associated bone loss; endocortical bone resorption; mechanical stimulation.衰老会导致松质骨和皮质间隔的骨质流失
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1075 次 机械激活的间充质衍生骨细胞通过细胞外囊泡介导的机制驱动血管生成 2025-6-23
Mechanically activated mesenchymal-derived bone cells drive vessel formation via an extracellular vesicle mediated mechanismKeywords: Osteoblast; VEGF; angiogenesis; mechanobiology
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852 次 血管炎性疾病和内皮表型 2025-6-17
Vascular Inflammatory Diseases and Endothelial PhenotypesKeywords: EC phenotypes; endothelial cell; inflammation; vascular diseases.内皮细胞排列在管腔表面，充当分隔血液和周围组织的
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967 次 微管蛋白乙酰化增强机械应力下小梁网细胞的微管稳定性 2025-6-16
Tubulin Acetylation Enhances Microtubule Stability in Trabecular Meshwork Cells Under Mechanical StressKeywords: trabecular meshwork, glaucoma, tubulin acetylation, mechanical stre
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1087 次 拉伸诱导的内皮细胞单层损伤的相关研究 2025-6-10
Stretch-induced damage in endothelial monolayersKeywords: Aging; Cell mechanics; Endothelium; Mechanobiology; Senescence; Stretch.由于血流的脉动性，包括流体剪切力、压力和循环拉伸在
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1045 次 视网膜神经节细胞经IL-12-SCGF-β串扰诱导干细胞衍生的神经保护作用 2025-6-9
Retinal ganglion cells induce stem cell-derived neuroprotection via IL-12 to SCGF-β crosstalkKWS：Retinal ganglion cells；stem cell；neuroprotection；IL-12；SCGF-β；cross
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1272 次 血管内皮-间充质串扰通过 Notch 信号驱动人成骨细胞的成骨分化 2025-6-4
Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through Notch signalingKeywords: Co-culture; Endothelial cells; Notch signaling; Osteoblast
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1194 次 TRPV4 抑制剂和机械负荷对减轻炎症的协同作用 2025-6-3
Synergetic role of TRPV4 inhibitor and mechanical loading on reducing inflammationKeywords: anti-inflammatory phenotype; inhibition, mechanical loading; macrophage polarization; mi
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1155 次 I 类 PI3Ks 激活小梁网细胞中拉伸诱导的自噬 2025-5-27
Class I PI3Ks activate stretch-induced autophagy in trabecular meshwork cellsKeywords: Autophagy; Glaucoma; Mechanical stress; PI3K; Primary cilia; Trabecular meshwork.眼压升高（IO
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992 次 内皮 IGFBP6 抑制血管炎症和动脉粥样硬化 2025-5-26
Endothelial IGFBP6 suppresses vascular inflammation and atherosclerosisKWS：IGFBP6；vascular inflammation；atherosclerosis动脉粥样硬化通常发生在血流紊乱（DF）区域，例如动脉分支或弯
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1172 次 c-REL串扰TXNIP-p38与非经典NF-κB通路协调紊乱血流区动脉粥样硬化 2025-5-20
Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathwaysKWS：c-REL, Shear stress, Endothe
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1370 次 动脉粥样硬化中血流诱导的内皮细胞重编程 2025-5-19
Flow-induced reprogramming of endothelial cells in atherosclerosisSubject terms: Cell biology, Systems biology动脉粥样硬化是一种主要影响动脉的多因素慢性炎症性疾病。内皮细胞功能障碍
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1324 次 E2F1诱导IL-6炎症循环介导癌症免疫，预测T细胞表型转换和治疗反应 2025-5-13
E2F1-induced autocrine IL-6 inflammatory loop mediates cancer-immune crosstalk that predicts T cell phenotype switching and therapeutic responsivenessKeywords: CD4 +/CD8 + T cells;